In 1- to 2-week-old kids, a generalized disease with severe gastrointestinal lesions predominates. 2,6,7,10,11 Clinical manifestation of disease depends on the age of the infected animal. Liver: multifocal, random, mild, necrotizing hepatitis with intranuclear viral inclusion bodiesĬaprine herpesvirus 1 (CpHV-1) is globally distributed alphaherpesvirus that occasionally causes disease and is less-commonly implicated as a cause of infectious abortion.Lung: multifocal, random, moderate, necrotizing pneumonia with intranuclear viral inclusion bodies.
Macrophages in and around these nodules have small amounts of globular, dark brown, intracytoplasmic pigment (presumably hemosiderin) Hepatocytes along the periphery often have eosinophilic intranuclear inclusions that peripheralize chromatin. Liver: Multiple random foci of hepatic necrosis disrupt the parenchyma and are composed of globular hypereosinophilic cell fragments and karyorrhectic debris admixed with small numbers of macrophages. At the periphery of these foci are degenerating cells with usually a single, eosinophilic intranuclear inclusion that measures approximately 5 um and peripheralizes the chromatin. Alveoli are filled with fine pink fibrillar material (fibrin) and pale pink fluid. Few macrophages, neutrophils, and erythrocytes are admixed. The alveolar septa are markedly expanded by flocculent pink cell debris, karyorrhectic material and fibrin (coagulative necrosis). Lung: Multiple random foci of necrosis that measure up to 1 mm wide disrupt the pulmonary parenchyma. The viral inclusions did not stain using bovine herpesvirus-1 (infectious bovine rhinotracheitis) antibody (immunohistochemistry). Aerobic bacterial culture of lung yielded no growth of pathogens.Ĭaprine herpesvirus (CapHV-1) PCR testing of a lung sample at Colorado State University Veterinary Diagnostic Laboratory detected nucleic acids (positive). Lung sections from both twins sank in formalin.Īn in-house real time reverse transcriptase multiplex rRT-PCR test using pooled liver had the following result: infectious bovine rhinotracheitis (IBR) was suspect positive, with a Ct of 38 tissues were negative for bovine respiratory syncytial virus (BRSV) and parainfluenza-3 (PI3). The lungs of the male twin had hundreds of disseminated, smooth, white, and flat pinpoint to 2.0 mm nodules within the lung parenchyma and on the pleural surfaces.
The female twin was grossly unremarkable. No placenta was submitted with the fetuses. This animal was submitted with a male twin. *The animal appears to be nearly full-term on gross examination and measures 46 cm from crown to rump. Unknown gestational age*, intact female, aborted dairy goat fetus ( Capra aegagrus hircus)
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